PLEIOTROPIC EFFECTS OF STATINS REVIEW



Pleiotropic Effects Of Statins Review

[Pleiotropic effects of statins] ResearchGate. 01/10/2012 · The pleiotropic effects of statins appear to result from improvements in endothelial function, a reduction in inflammatory mediators, a decline in the development of atheroma through the stabilization of atheromatous plaques, and the inhibition of cardiac hypertrophy through an antioxidant mechanism. Long-term statin use may reduce morbidity, Statins induce kruppel-like factor-2 mRNA in ECs, which may be required for eNOS expression. 133 Statins reduce T proliferation through kruppel-like factor-2, which may explain some of their immunomodulatory effects. 134. Statins may exert pleiotropic effects by enhancing the mobilization of endothelial progenitor cells..

PLEIOTROPIC EFFECTS OF STATINS PubMed Central (PMC)

Evaluation of the Pleiotropic Effects of Statins. In particular, inhibition of Rho and one of its downstream targets, Rho kinase, may be a predominant mechanism contributing to the pleiotropic effects of statins. The aim of the present review is to provide an update on the non-cholesterol-dependent statin effects in the cardiovascular system and highlight some of the recent findings from bench, 01/10/2012 · The pleiotropic effects of statins appear to result from improvements in endothelial function, a reduction in inflammatory mediators, a decline in the development of atheroma through the stabilization of atheromatous plaques, and the inhibition of cardiac hypertrophy through an antioxidant mechanism. Long-term statin use may reduce morbidity.

The association between statins and incident diabetes mellitus is also not mediated by any observable pleiotropic effects. The evidence suggests that most, if not all, of statins’ effects are mediated through their LDL (low-density lipoprotein) lowering mechanism. Objective: The aim of this review is to describe the most relevant and updated evidence regarding the pleiotropic effects of statins in endocrine disorders. Methods: We did a systematic review of scientific articles published in PubMed regarding the effects of statins on the different aspects of the endocrine system up until June 5th of 2018.

Effects of Statins by Different Tissues and Cell Types: There is interplay between the pleiotropic effects of statins and the reduction in atherosclerosis also plays a role in the possible reduction of atrial fibrillation or ventricular tachyarrhythmias that may be seen with statin use. SMC – smooth muscle cell, IL- interleukin, ROCK – rho The Pleiotropic Effects of Statins – From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia Author(s): Adam Oesterle , The Section of Cardiology, Department of Medicine, The University of Chicago, Chicago, IL 60637, United States James K. Liao* .

Evidence for the pleiotropic effects of statins in heart failure comes largely from retrospective and subgroup analyses of large studies. When statin therapy is compared with placebo, or when high-dose statin therapy is compared with low-dose treatment, a lower incidence of heart failure or hospitalization is observed. Despite promising Effects of Statins by Different Tissues and Cell Types: There is interplay between the pleiotropic effects of statins and the reduction in atherosclerosis also plays a role in the possible reduction of atrial fibrillation or ventricular tachyarrhythmias that may be seen with statin use. SMC – smooth muscle cell, IL- interleukin, ROCK – rho

The present review article demonstrates the pleiotropic effects of statins beyond their lipid lowering effects. Moreover, the underlying mechanisms involved in stain-induced cardioprotection … Background. Statins have anti-inflammatory, immunomodulatory, antithrombotic, vascular, and other non–LDL-C-lowering effects. It is unclear whether these pleiotropic effects contribute to cardiovascular risk reduction beyond that expected from LDL-C reduction alone.

Objective: The aim of this review is to describe the most relevant and updated evidence regarding the pleiotropic effects of statins in endocrine disorders. Methods: We did a systematic review of scientific articles published in PubMed regarding the effects of statins on the different aspects of the endocrine system up until June 5th of 2018. Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although

Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although The present review considers the potential pleiotropic effects of statins and the evidence indicative of the “real world” benefit from these effects in patients with cardiovascular disease (CVD). Some of these cholesterol-independent effects of statins involve improved endothelial function, stability of atherosclerotic plaques, attenuation

Both the continuation of pre-operative statins and the withdrawal of statins in those assigned to placebo appeared safe. Another negative RCT for the pleiotropic effects of statins makes the pursuit of further trials harder to justify in critical care. Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although

In particular, inhibition of Rho and one of its downstream targets, Rho kinase, may be a predominant mechanism contributing to the pleiotropic effects of statins. The aim of the present review is to provide an update on the non-cholesterol-dependent statin effects in the cardiovascular system and highlight some of the recent findings from bench Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Statins through abolition of TLR4

PLEIOTROPIC EFFECTS OF STATINS PubMed Central (PMC)

pleiotropic effects of statins review

Pleiotropic effects of statins PubMed Central (PMC). Pleiotropic effects of statins: benefit beyond cholesterol reduction? A meta-regression analysis: Robinson J G, Smith B, Maheshwari N, Schrott H CRD summary. The review sought to determine whether statins reduced the risk of coronary heart disease more than other low-density lipoprotein cholesterol-lowering interventions. The authors concluded that pleiotropic effects of statins did not seem, than hydrophilic statins such as pravastatin and rosuvastatin, which are primarily targeted to the liver. The observation, however, that hydrophilic statins have similar pleiotropic effects as lipophilic statins puts into question whether there are really any cholesterol-independent effects of statins. Indeed,.

What Are Pleiotropic Effects? The Role of Statins in. Objective: The aim of this review is to describe the most relevant and updated evidence regarding the pleiotropic effects of statins in endocrine disorders. Methods: We did a systematic review of scientific articles published in PubMed regarding the effects of statins on the different aspects of the endocrine system up until June 5th of 2018., The present review article demonstrates the pleiotropic effects of statins beyond their lipid lowering effects. Moreover, the underlying mechanisms involved in stain-induced cardioprotection ….

Pleiotropic effects of statins on the treatment of chronic

pleiotropic effects of statins review

Evaluation of the Pleiotropic Effects of Statins. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Statins through abolition of TLR4 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Statins through abolition of TLR4.

pleiotropic effects of statins review


lonate-independent effects of any statin have been reported. Evidence of Statin Pleiotropy in Clinical Trials The concept of anti-inflammatory pleiotropic effects of statins has been tested for perioperative risk reduction. Several studies pro-vide evidence for beneficial effects of statins on atrial fibrillation Objective: The aim of this review is to describe the most relevant and updated evidence regarding the pleiotropic effects of statins in endocrine disorders. Methods: We did a systematic review of scientific articles published in PubMed regarding the effects of statins on the different aspects of the endocrine system up until June 5th of 2018.

lonate-independent effects of any statin have been reported. Evidence of Statin Pleiotropy in Clinical Trials The concept of anti-inflammatory pleiotropic effects of statins has been tested for perioperative risk reduction. Several studies pro-vide evidence for beneficial effects of statins on atrial fibrillation Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review. Ilanna Mara Gomes Estanislau Department of Clinical Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.

Apparently, the beneficial effects of statins might be partially mediated by the pleiotropic anti‐inflammatory effect that this drug has on the periodontal tissue. Protection from periodontal disease was observed in the results of Lindy et al. lonate-independent effects of any statin have been reported. Evidence of Statin Pleiotropy in Clinical Trials The concept of anti-inflammatory pleiotropic effects of statins has been tested for perioperative risk reduction. Several studies pro-vide evidence for beneficial effects of statins on atrial fibrillation

In this review, we will comment on the pleiotropic effects of statins and will illustrate some biotransformations nowadays implemented for statin synthesis. View Show abstract Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although

16/08/2014 · This review will explore the pleiotropic effects of statins, discuss the current use of statins for bone regeneration, particularly with regard to biomaterials-based controlled delivery, and offer perspectives on the challenges and future directions of this emerging area of bone tissue engineering. Effects of Statins by Different Tissues and Cell Types: There is interplay between the pleiotropic effects of statins and the reduction in atherosclerosis also plays a role in the possible reduction of atrial fibrillation or ventricular tachyarrhythmias that may be seen with statin use. SMC – smooth muscle cell, IL- interleukin, ROCK – rho

Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although 01/10/2012 · The pleiotropic effects of statins appear to result from improvements in endothelial function, a reduction in inflammatory mediators, a decline in the development of atheroma through the stabilization of atheromatous plaques, and the inhibition of cardiac hypertrophy through an antioxidant mechanism. Long-term statin use may reduce morbidity

lonate-independent effects of any statin have been reported. Evidence of Statin Pleiotropy in Clinical Trials The concept of anti-inflammatory pleiotropic effects of statins has been tested for perioperative risk reduction. Several studies pro-vide evidence for beneficial effects of statins on atrial fibrillation than hydrophilic statins such as pravastatin and rosuvastatin, which are primarily targeted to the liver. The observation, however, that hydrophilic statins have similar pleiotropic effects as lipophilic statins puts into question whether there are really any cholesterol-independent effects of statins. Indeed,

Download Citation [Pleiotropic effects of statins] Systematization of pleiotropic actions of statins is presented with special stress on effects important for prevention of atherosclerotic 12/03/2013 · It would be a mistake to attribute all beneficial outcomes obtained from statins solely to cholesterol lowering. Statins have pleiotropic effects—that is, they are simultaneously capable of producing more than one benefit, and in cardiovascular risk reduction, they accomplish more than simply lowering cholesterol.

PLEIOTROPIC EFFECTS OF STATINS Annual Review of

pleiotropic effects of statins review

PLEIOTROPIC EFFECTS OF STATINS PubMed Central (PMC). The present review considers the potential pleiotropic effects of statins and the evidence indicative of the “real world” benefit from these effects in patients with cardiovascular disease (CVD). Some of these cholesterol-independent effects of statins involve improved endothelial function, stability of atherosclerotic plaques, attenuation, Effects of Statins by Different Tissues and Cell Types: There is interplay between the pleiotropic effects of statins and the reduction in atherosclerosis also plays a role in the possible reduction of atrial fibrillation or ventricular tachyarrhythmias that may be seen with statin use. SMC – smooth muscle cell, IL- interleukin, ROCK – rho.

Statins The end of the road for pleiotropic effects in

Pleiotropic effects of statins SpringerLink. The present review considers the potential pleiotropic effects of statins and the evidence indicative of the “real world” benefit from these effects in patients with cardiovascular disease (CVD). Some of these cholesterol-independent effects of statins involve improved endothelial function, stability of atherosclerotic plaques, attenuation, Both the continuation of pre-operative statins and the withdrawal of statins in those assigned to placebo appeared safe. Another negative RCT for the pleiotropic effects of statins makes the pursuit of further trials harder to justify in critical care..

Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review Ilanna Mara Gomes Estanislau,1 Icrólio Ribeiro Colares Terceiro,1 Mario Roberto Pontes Lisboa,2 Patrícia de Barros Teles,2 Rosimary de Sousa Carvalho,1 Ricardo Souza Martins1 & Maria Mônica Studart Mendes Moreira1 1DepartmentofClinicalDentistry,FacultyofPharmacy,DentistryandNursing Read "PLEIOTROPIC EFFECTS OF STATINS, Annual Review of Pharmacology and Toxicology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Pleiotropic effects of statins. Article · Literature Review (PDF Available) · October 2015 with 355 Reads How we measure 'reads' A 'read' is counted each time someone views a publication summary In addition to stimulating properties in the bone tissue, statins also have other pleiotropic effects, such as anti-inflammatory and immunomodulatory effects 16. These drugs have been widely studied because they might be beneficial in various dental specialties in which bone formation, reduction of inflammation and immunomodulation are essential for a successful treatment 17 , 18 .

Objective: The aim of this review is to describe the most relevant and updated evidence regarding the pleiotropic effects of statins in endocrine disorders. Methods: We did a systematic review of scientific articles published in PubMed regarding the effects of statins on the different aspects of the endocrine system up until June 5th of 2018. Recently, several studies have shown that an intensive lipid-lowering regimen with a statin provides greater protection against death or major cardiovascular events than does a standard regimen. Summary: This review summarizes the new findings in these pleiotropic effects and describes their impact on vascular processes.",

These ‘‘pleiotropic’’ effects include attenuation of vascular inflammation, improved endothelial cell function, stabilization of atherosclerotic plaque, decreased vascular smooth muscle cell migration and proliferation, and inhibition of platelet aggregation. This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. 19/04/2005 · The pleiotropic effects of statins are related to the reduced formation of isoprenoids, which are responsible for post-translational modification of proteins (for review, see Werner et al. ). Among those proteins, the reduced prenylation and thus activity of small G-proteins (Ras, Rho) appears to be of major importance.

Pleiotropic Effects of Statins: Benefit Beyond Cholesterol Reduction? A Meta-Regression Analysis Jennifer G. Robinson, MD, MPH,* Brian Smith, MS, PHD,† Nidhi Maheshwari, MBBS,* Helmut Schrott, MD* Iowa City, Iowa OBJECTIVES This study sought to determine whether statins reduce coronary heart disease (CHD) risk Recently, several studies have shown that an intensive lipid-lowering regimen with a statin provides greater protection against death or major cardiovascular events than does a standard regimen. Summary: This review summarizes the new findings in these pleiotropic effects and describes their impact on vascular processes.",

Such cholesterol-independent effects were called the pleiotropic effects of statins.[1,9] “Pleiotropy” has originated from the Greek words “pleion,” which means more, and “tropy” meaning response or stimuli. Though pleiotropic effects are defined as a single gene affecting multiple systems or determining more than one phenotype These ‘‘pleiotropic’’ effects include attenuation of vascular inflammation, improved endothelial cell function, stabilization of atherosclerotic plaque, decreased vascular smooth muscle cell migration and proliferation, and inhibition of platelet aggregation. This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level.

Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although 19/04/2005 · The pleiotropic effects of statins are related to the reduced formation of isoprenoids, which are responsible for post-translational modification of proteins (for review, see Werner et al. ). Among those proteins, the reduced prenylation and thus activity of small G-proteins (Ras, Rho) appears to be of major importance.

These ‘‘pleiotropic’’ effects include attenuation of vascular inflammation, improved endothelial cell function, stabilization of atherosclerotic plaque, decreased vascular smooth muscle cell migration and proliferation, and inhibition of platelet aggregation. This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. The Pleiotropic Effects of Statins – From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia Author(s): Adam Oesterle , The Section of Cardiology, Department of Medicine, The University of Chicago, Chicago, IL 60637, United States James K. Liao* .

Several studies have shown that statins, having an important effect in the prevention of acute coronary syndromes, are also able to prevent heart failure (HF) in patients with coronary artery disease. This review summarizes the experimental and clinical evidence regarding the role of statins in the management of HF. Recently, several studies have shown that an intensive lipid-lowering regimen with a statin provides greater protection against death or major cardiovascular events than does a standard regimen. Summary: This review summarizes the new findings in these pleiotropic effects and describes their impact on vascular processes.",

In this review, we will comment on the pleiotropic effects of statins and will illustrate some biotransformations nowadays implemented for statin synthesis. View Show abstract Both the continuation of pre-operative statins and the withdrawal of statins in those assigned to placebo appeared safe. Another negative RCT for the pleiotropic effects of statins makes the pursuit of further trials harder to justify in critical care.

Pleiotropic effects of statins. Article · Literature Review (PDF Available) · October 2015 with 355 Reads How we measure 'reads' A 'read' is counted each time someone views a publication summary Such cholesterol-independent effects were called the pleiotropic effects of statins. , "Pleiotropy" has originated from the Greek words "pleion," which means more, and "tropy" meaning response or stimuli. Though pleiotropic effects are defined as a single gene affecting multiple systems or determining more than one phenotype, lately statin

Objective: The aim of this review is to describe the most relevant and updated evidence regarding the pleiotropic effects of statins in endocrine disorders. Methods: We did a systematic review of scientific articles published in PubMed regarding the effects of statins on the different aspects of the endocrine system up until June 5th of 2018. The noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability) as being the major modulators of clinical benefit. This review will focus on the potential beneficial effects of statin therapy on a number of the

Effects of Statins by Different Tissues and Cell Types: There is interplay between the pleiotropic effects of statins and the reduction in atherosclerosis also plays a role in the possible reduction of atrial fibrillation or ventricular tachyarrhythmias that may be seen with statin use. SMC – smooth muscle cell, IL- interleukin, ROCK – rho In particular, inhibition of Rho and one of its downstream targets, Rho kinase, may be a predominant mechanism contributing to the pleiotropic effects of statins. The aim of the present review is to provide an update on the non-cholesterol-dependent statin effects in the cardiovascular system and highlight some of the recent findings from bench

Pleiotropic effects of statins on the treatment of chronic

pleiotropic effects of statins review

The Pleiotropic Effects of Statins – From Coronary Artery. These ‘‘pleiotropic’’ effects include attenuation of vascular inflammation, improved endothelial cell function, stabilization of atherosclerotic plaque, decreased vascular smooth muscle cell migration and proliferation, and inhibition of platelet aggregation. This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level., Such cholesterol-independent effects were called the pleiotropic effects of statins.[1,9] “Pleiotropy” has originated from the Greek words “pleion,” which means more, and “tropy” meaning response or stimuli. Though pleiotropic effects are defined as a single gene affecting multiple systems or determining more than one phenotype.

Pleiotropic effects of statins SpringerLink

pleiotropic effects of statins review

Evaluation of the Pleiotropic Effects of Statins. Evidence for the pleiotropic effects of statins in heart failure comes largely from retrospective and subgroup analyses of large studies. When statin therapy is compared with placebo, or when high-dose statin therapy is compared with low-dose treatment, a lower incidence of heart failure or hospitalization is observed. Despite promising 16/08/2014 · This review will explore the pleiotropic effects of statins, discuss the current use of statins for bone regeneration, particularly with regard to biomaterials-based controlled delivery, and offer perspectives on the challenges and future directions of this emerging area of bone tissue engineering..

pleiotropic effects of statins review

  • Pleiotropic effects of statins benefit beyond cholesterol
  • Pleiotropic effects of statins A boulevard to
  • Pleiotropic Effects of Statins on the Cardiovascular System

  • 19/04/2005 · The pleiotropic effects of statins are related to the reduced formation of isoprenoids, which are responsible for post-translational modification of proteins (for review, see Werner et al. ). Among those proteins, the reduced prenylation and thus activity of small G-proteins (Ras, Rho) appears to be of major importance. Effects of Statins by Different Tissues and Cell Types: There is interplay between the pleiotropic effects of statins and the reduction in atherosclerosis also plays a role in the possible reduction of atrial fibrillation or ventricular tachyarrhythmias that may be seen with statin use. SMC – smooth muscle cell, IL- interleukin, ROCK – rho

    In addition to stimulating properties in the bone tissue, statins also have other pleiotropic effects, such as anti-inflammatory and immunomodulatory effects 16. These drugs have been widely studied because they might be beneficial in various dental specialties in which bone formation, reduction of inflammation and immunomodulation are essential for a successful treatment 17 , 18 . The present review article demonstrates the pleiotropic effects of statins beyond their lipid lowering effects. Moreover, the underlying mechanisms involved in stain-induced cardioprotection …

    Furthermore, statins have beneficial extrahepatic effects on the immune system, CNS, and bone. Many of these pleiotropic effects are mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules. In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins. Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies

    Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review. Ilanna Mara Gomes Estanislau Department of Clinical Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil. Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review. Ilanna Mara Gomes Estanislau Department of Clinical Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Brazil.

    The noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability) as being the major modulators of clinical benefit. This review will focus on the potential beneficial effects of statin therapy on a number of the In addition to stimulating properties in the bone tissue, statins also have other pleiotropic effects, such as anti-inflammatory and immunomodulatory effects 16. These drugs have been widely studied because they might be beneficial in various dental specialties in which bone formation, reduction of inflammation and immunomodulation are essential for a successful treatment 17 , 18 .

    The noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability) as being the major modulators of clinical benefit. This review will focus on the potential beneficial effects of statin therapy on a number of the The present review considers the potential pleiotropic effects of statins and the evidence indicative of the “real world” benefit from these effects in patients with cardiovascular disease (CVD). Some of these cholesterol-independent effects of statins involve improved endothelial function, stability of atherosclerotic plaques, attenuation

    Background. Statins have anti-inflammatory, immunomodulatory, antithrombotic, vascular, and other non–LDL-C-lowering effects. It is unclear whether these pleiotropic effects contribute to cardiovascular risk reduction beyond that expected from LDL-C reduction alone. Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although

    Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Statins through abolition of TLR4 Background. Statins have anti-inflammatory, immunomodulatory, antithrombotic, vascular, and other non–LDL-C-lowering effects. It is unclear whether these pleiotropic effects contribute to cardiovascular risk reduction beyond that expected from LDL-C reduction alone.

    than hydrophilic statins such as pravastatin and rosuvastatin, which are primarily targeted to the liver. The observation, however, that hydrophilic statins have similar pleiotropic effects as lipophilic statins puts into question whether there are really any cholesterol-independent effects of statins. Indeed, 01/10/2012 · The pleiotropic effects of statins appear to result from improvements in endothelial function, a reduction in inflammatory mediators, a decline in the development of atheroma through the stabilization of atheromatous plaques, and the inhibition of cardiac hypertrophy through an antioxidant mechanism. Long-term statin use may reduce morbidity

    Such cholesterol-independent effects were called the pleiotropic effects of statins.[1,9] “Pleiotropy” has originated from the Greek words “pleion,” which means more, and “tropy” meaning response or stimuli. Though pleiotropic effects are defined as a single gene affecting multiple systems or determining more than one phenotype Because Rho is major target of geranylgeranylation, inhibition of Rho and its downstream target, Rho-kinase, is a likely mechanism mediating some of the pleiotropic effects of statins on the vascular wall (34, 35).Each member of the Rho GTPase family, which consists of RhoA, Rac, and Cdc42, serves specific functions in terms of cell shape, motility, secretion, and proliferation, although

    Objective: The aim of this review is to describe the most relevant and updated evidence regarding the pleiotropic effects of statins in endocrine disorders. Methods: We did a systematic review of scientific articles published in PubMed regarding the effects of statins on the different aspects of the endocrine system up until June 5th of 2018. Furthermore, statins have beneficial extrahepatic effects on the immune system, CNS, and bone. Many of these pleiotropic effects are mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules. In particular, inhibition of small GTP-binding proteins, Rho, Ras, and Rac, whose proper membrane localization and function are dependent on isoprenylation, may play an important role in mediating the pleiotropic effects of statins.

    Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Statins through abolition of TLR4 Pleiotropic Effects of Statins: Benefit Beyond Cholesterol Reduction? A Meta-Regression Analysis Jennifer G. Robinson, MD, MPH,* Brian Smith, MS, PHD,† Nidhi Maheshwari, MBBS,* Helmut Schrott, MD* Iowa City, Iowa OBJECTIVES This study sought to determine whether statins reduce coronary heart disease (CHD) risk

    Statins induce kruppel-like factor-2 mRNA in ECs, which may be required for eNOS expression. 133 Statins reduce T proliferation through kruppel-like factor-2, which may explain some of their immunomodulatory effects. 134. Statins may exert pleiotropic effects by enhancing the mobilization of endothelial progenitor cells. Both the continuation of pre-operative statins and the withdrawal of statins in those assigned to placebo appeared safe. Another negative RCT for the pleiotropic effects of statins makes the pursuit of further trials harder to justify in critical care.

    Evidence for the pleiotropic effects of statins in heart failure comes largely from retrospective and subgroup analyses of large studies. When statin therapy is compared with placebo, or when high-dose statin therapy is compared with low-dose treatment, a lower incidence of heart failure or hospitalization is observed. Despite promising Pleiotropic effects of statins. Article · Literature Review (PDF Available) · October 2015 with 355 Reads How we measure 'reads' A 'read' is counted each time someone views a publication summary